Presence of key drug resistance mutations in isolates from untreated patients of Abidjan, Côte d'Ivoire: ANRS 1257 study.
نویسندگان
چکیده
A total of 107 HIV-1 isolates from untreated adult patients recruited in Abidjan, CMte d'Ivoire, in 2001 and 2002 were sequenced in the env, reverse transcriptase (RT), and protease genes. The results show that CRF02_AG is still predominant in this west African population; key mutations of resistance to antiretroviral drugs (NRTI, NNRTI, and PIs) were detected in 5.6% of the patients. We hypothesize that these resistant mutants have been acquired through horizontal transmission. Compared to a previous study carried out by our group in 1997-2000 in a similar population of Abidjan, it seems that there is a dynamic process of resistance and that a survey will be necessary.
منابع مشابه
HIV-1 antiretroviral drug resistance in recently infected patients in Abidjan, Côte d'Ivoire: A 4-year survey, 2002-2006.
We performed HIV-1 drug resistance genotypic analysis of viral isolates from 100 antiretroviral (ARV)-naive, recently HIV-1-infected (between 2002 and 2006) individuals from Abidjan (Côte d'Ivoire). The overall prevalence of HIV-1 variants with resistance mutations to reverse transcriptase, protease, or fusion inhibitors was 6%. The majority of isolates were CRF02_AG. Compared with a previous s...
متن کاملOccurrence and Antimicrobial Resistance of Enterococcus spp. Isolated from Lettuce and Irrigation Water in Abidjan, Côte d\'Ivoire
Background: Enterococcus spp., belonging to the group of lactic acid bacteria, are Gram-positive ubiquitous commensals of the intestines of human beings as well as warm-blooded animals. The main objective of this study was to determine the occurrence and antimicrobial resistance of Enterococcus spp. isolated from lettuce and irrigation water in Abidjan, Côte d'Ivoire. Methods: A total of...
متن کاملVariation in blood count parameters of children aged 5 to 11 years in Abidjan, Côte d\'Ivoire
Background: In Côte d’Ivoire, as in most developing countries, the reference values of hematological indices currently in use come from data collected from populations living in industrialized countries. The aim of this study was to determine variations in the childchr('39')s blood count in Cote dchr('39')Ivoire. Materials and Methods: This descriptive cross-sectional study has focused on 310 ...
متن کاملClonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Côte d'Ivoire).
We have investigated the genotype at 14 enzyme-encoding loci in 275 isolates of the pathogenic yeast Candida albicans sampled from 42 HIV-positive patients (all but one with AIDS) from Abidjan (Côte d'Ivoire). We separately analyzed the following variables: patient, residence, age, gender, T cell count, hospitalization (yes or no), drug treatment, date of sampling, multilocus genotype, and sero...
متن کاملPrevalence and Antimicrobial Resistance of Thermophilic Campylobacter Isolated from Chicken in Côte d'Ivoire
Thermophilic Campylobacters are major causes of gastroenteritis in human. The main risk factor of infection is consumption of contaminated or by cross-contaminated poultry meat. In Côte d'Ivoire, gastroenteritis is usually observed but no case of human campylobacteriosis has been formally reported to date. The aims of this study were to determine prevalence and antimicrobial resistance of Campy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- AIDS research and human retroviruses
دوره 19 8 شماره
صفحات -
تاریخ انتشار 2003